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Description for Protein HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.34
    KEGG - Orthology:
    K00021
    KEGG - Pathway(s):
    hsa00900; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    3-Hydroxy-3-methylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Beta-hydroxy-beta-methyl-glutaryl-CoA reductase; EC 1.1.1.34
    Approved Symbol:
    HMGCR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (S)-Hmg-Coa(db);
  • 1,4-Dithiothreitol(db);
  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • 3-Hydroxy-3-Methyl-Glutaric Acid(db);
  • 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID(db);
  • Adenosine-5'-Diphosphate(db);
  • Atorvastatin(db);
  • Cerivastatin(db);
  • Coenzyme A(db);
  • Fluvastatin(db);
  • Lovastatin(db);
  • Mevastatin(db);
  • NADH(db);
  • Pravastatin(db);
  • Rosuvastatin(db);
  • Simvastatin(db)

    Associated Genetic Diseases:

  • Statins, attenuated cholesterol lowering by(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 5
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 00836 Entrez Gene ID: 3156 OMIM ID: 142910 Swissprot Accession: P04035;