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Description for Protein HLA-DPA1

major histocompatibility complex, class II, DP alpha 1
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IGC: Immunoglobulin C-Type
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06752
    KEGG - Pathway(s):
    hsa04514; hsa04612; hsa04672; hsa04940; hsa05140; hsa05310; hsa05320; hsa05322; hsa05330; hsa05332; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HLADP; HLA-SB histocompatibility type; HLASB; Major histocompatibility complex, class II, DP alpha 1; HLA-SB alpha chain; MHC class II DP3-alpha; DP(W3); DP(W4); HLA class II histocompatibility antigen, DP alpha chain
    Approved Symbol:
    HLA-DPA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00835 Entrez Gene ID: 3113 OMIM ID: 142880 Swissprot Accession: P20036; Q5STP1;