Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ACACA

acetyl-CoA carboxylase alpha
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 8)
Summary:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.4.14; 6.4.1.2
KEGG - Orthology:
K11262
KEGG - Pathway(s):
hsa00061; hsa00620; hsa00640; hsa01100; hsa04910
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Acetyl-CoA carboxylase 1; ACC alpha; Biotin carboxylase; ACC1; Acetyl-Coenzyme A carboxylase alpha; ACAC; ACC; ACCA; EC 6.4.1.2; Acetyl-Coenzyme A carboxylase alpha isoform 4; Acetyl-Coenzyme A carboxylase alpha isoform 1; Acetyl-Coenzyme A carboxylase alpha isoform 2; Acetyl-Coenzyme A carboxylase alpha isoform 3
Approved Symbol:
ACACA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 110
Human (de-) phosphorylation sites: 110; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Biotin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01938 Entrez Gene ID: 31 OMIM ID: 200350 Swissprot Accession: Q7Z5W8; B2ZZ90; Q13085;