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Description for Protein HK1

hexokinase 1
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/0)
(membrane: 2; microparticles: 1; platelet: 6; secretome: 4)
Summary:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.1
KEGG - Orthology:
K00844
KEGG - Pathway(s):
hsa00010; hsa00051; hsa00052; hsa00500; hsa00520; hsa00524; hsa01100; hsa04910; hsa04930
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
EC 2.7.1.1; HXK1; Brain form hexokinase; Glycolytic enzyme; HK1-sa; HK1-sb; Hexokinase 1 isoform HKI-ta/tb; HK1-ta; HK1-tb; Hexokinase 1 isoform HKI; Hexokinase 1 isoform HKI-R; Hexokinase 1 isoform HKI-td
Approved Symbol:
HK1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 12
Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • Alpha-D-Glucose-6-Phosphate(db);
  • Beta-D-Glucose(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Hexokinase deficiency hemolytic anemia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00809 Entrez Gene ID: 3098 OMIM ID: 142600 Swissprot Accession: P19367; B3KXY9; Q59FD4;