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Description for Protein NRG1

neuregulin 1
9 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EGF: Epidermal growth factor-like domain.
  • TM: Transmembrane domain
  • IGC2: Immunoglobulin C-2 Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05455
    KEGG - Pathway(s):
    hsa04012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Heregulin, alpha; HGL; HRGA; Neu differentiation factor; NDF; Glial growth factor 2; GGF2; Acetylcholine receptor inducing activity; ARIA; GGF; HRG; HRG1; SMDF; Glial growth factor; Sensory and motor neuron derived factor; Heregulin, alpha (45kD, ERBB2 p185-activator); Neuregulin 1 isoform HRG-gamma; Neuregulin 1 isoform HRG-beta2; Neuregulin 1 isoform HRG-alpha; Neuregulin 1 isoform HRG-beta3; Neuregulin 1 isoform SMDF; Neuregulin 1 isoform ndf43; Neuregulin 1 isoform GGF; Neuregulin 1 isoform GGF2; Neuregulin 1 isoform HRG-beta1; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1
    Approved Symbol:
    NRG1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 9 : 1
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00802 Entrez Gene ID: 3084 OMIM ID: 142445 Swissprot Accession: B0FWZ3; Q7RTW3; B7Z1D7;