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Description for Protein HGF

hepatocyte growth factor (hepapoietin A; scatter factor)
15 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05460
    KEGG - Pathway(s):
    hsa04060; hsa04510; hsa05144; hsa05200; hsa05211; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Scatter factor; SF; Lung fibroblast derived mitogen; Hepatopoeitin A; HGFB; HPTA; F TCF; Fibroblast derived tumor cytotoxic factor; Hepatocyte growth factor isoform 1 preproprotein; Hepatocyte growth factor isoform 2 precursor; Hepatocyte growth factor isoform 3 precursor; Hepatocyte growth factor isoform 4 precursor; Hepatocyte growth factor isoform 5 precursor; NK2
    Approved Symbol:
    HGF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N,O6-Disulfo-Glucosamine(db);
  • O2-Sulfo-Glucuronic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00799 Entrez Gene ID: 3082 OMIM ID: 608265 Swissprot Accession: P14210;