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Description for Protein KCNIP2

Kv channel interacting protein 2
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    KChIP2b; KChIP2c; KChIP2a; KCHIP2; Kv channel interacting protein 2; Kv channel interacting protein 2 isoform 2; Kv channel interacting protein 2 isoform 3; Kv channel interacting protein 2 isoform 4; Kv channel interacting protein 2 isoform 5; Kv channel interacting protein 2 isoform 6; Kv channel interacting protein 2 isoform 1; Kv channel interacting protein 2 isoform 7; Kv channel interacting protein 2 isoform 8; KChIP2.2; KChIP2L; MGC17241; DKFZp566L1246; A-type potassium channel modulatory protein 2; Cardiac voltage gated potassium channel modulatory subunit
    Approved Symbol:
    KCNIP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06880 Entrez Gene ID: 30819 OMIM ID: 604661 Swissprot Accession: Q3YAC9; Q9NS61; Q3YAC6;