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Description for Protein ANXA5

annexin A5
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 4)
Summary:
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • ANX: Annexin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Annexin 5; Annexin A5; ANX5; Endonexin II; ENX2; Placental anticoagulant protein I; Vascular anticoagulant alpha; Lipocortin V; Placental protein 4; PP4; Anchorin CII; VAC alpha; Calphobindin I; CBP I; PAP I
    Approved Symbol:
    ANXA5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid(db);
  • 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid(db);
  • K201(db);
  • L-Alpha-Glycerophosphorylethanolamine(db);
  • L-Alpha-Glycerophosphorylserine(db);
  • N,O6-Disulfo-Glucosamine(db);
  • Thioproline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00568 Entrez Gene ID: 308 OMIM ID: 131230 Swissprot Accession: P08758; A8MTE3;