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Description for Protein HBD

hemoglobin, delta
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 3; secretome: 1)
Summary:
The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K13823
KEGG - Pathway(s):
hsa05144
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
-
Approved Symbol:
HBD
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Delta-0-thalassemia(Pd);
  • Delta-plus-thalassemia(Pd);
  • Delta-thalassemia(Pd);
  • Delta-zero-thalassemia, Knossos type(Pd);
  • Hemoglobin A(Pd) Agrinio(Pd);
  • Hemoglobin A(Pd) Babinga(Pd);
  • Hemoglobin A(Pd) Campania(Pd);
  • Hemoglobin A(Pd) Canada(Pd);
  • Hemoglobin A(Pd) Coburg(Pd);
  • Hemoglobin A(Pd) Corfu(Pd);
  • Hemoglobin A(Pd) Fitzroy(Pd);
  • Hemoglobin A(Pd) Flatbush(Pd);
  • Hemoglobin A(Pd) Honai(Pd);
  • Hemoglobin A(Pd) Indonesia(Pd);
  • Hemoglobin A(Pd) Lapri(Pd);
  • Hemoglobin A(Pd) Lucania(Pd);
  • Hemoglobin A(Pd) Manzanares(Pd);
  • Hemoglobin A(Pd) Melbourne(Pd);
  • Hemoglobin A(Pd) Metaponto(Pd);
  • Hemoglobin A(Pd) Monreale(Pd);
  • Hemoglobin A(Pd) Niigata(Pd);
  • Hemoglobin A(Pd) Ninive(Pd);
  • Hemoglobin A(Pd) Nyu(Pd);
  • Hemoglobin A(Pd) Parkville(Pd);
  • Hemoglobin A(Pd) Pelendri(Pd);
  • Hemoglobin A(Pd) Puglia(Pd);
  • Hemoglobin A(Pd) Roosevelt(Pd);
  • Hemoglobin A(Pd) Sant' Antioco(Pd);
  • Hemoglobin A(Pd) Sphakia(Pd);
  • Hemoglobin A(Pd) Victoria(Pd);
  • Hemoglobin A(Pd) Wrens(Pd);
  • Hemoglobin A(Pd) Yokoshima(Pd);
  • Hemoglobin A(Pd) Zagreb(Pd);
  • Hemoglobin A(Pd)-prime(Pd);
  • Hemoglobin Delta variants, molecular defect unknown(Pd);
  • Hemoglobin Lepore (Baltimore)(Pd);
  • Hemoglobin Lepore (Boston)(Pd);
  • Hemoglobin Lepore (Hollandia)(Pd);
  • Hemoglobin Parchman(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00787 Entrez Gene ID: 3045 OMIM ID: 142000 Swissprot Accession: P02042; A0N071;