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Description for Protein HBB

hemoglobin, beta

13 total interacting proteins; 9 platelet interacting proteins

Platelet Evidence (proteome studies/others : 8/1)
(membrane: 1; microparticles: 1; platelet: 7; secretome: 1)

Summary:

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq] (PubMed Links)

Domains and Motifs:

None Available

Gene Ontology:

Gene Ontology Annotations

KEGG - Enzyme ID(s):

None Available

KEGG - Orthology:

K13823

KEGG - Pathway(s):

hsa05144
(The yellow boxes represents platelet proteins)

Nomenclature / Alternative Names:

Approved Symbol:

HBB

(De-) Phosphorylations:

Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8;	No platelet phosphorylation sites

Phosphorylation Targets:

Total phosphorylation targets: 0
Human phosphorylation targets: 0;	Predicted platelet targets: 0

Protein Characteristics:

Isoform-specific Information

Associated Drugs (DrugBank Accession):

1,3,5-BENZENETRICARBOXYLIC ACID(db);

2,6-DICARBOXYNAPHTHALENE(db);

2-[(2-methoxy-5-methylphenoxy)methyl]pyridine(db);

2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID(db);

2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID(db);

2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID(db);

4-Carboxycinnamic Acid(db);

4-[(5-methoxy-2-methylphenoxy)methyl]pyridine(db);

Heme(db);

Iron Dextran(db);

SEBACIC ACID(db)

Associated Genetic Diseases:

beta-plus-thalassemia(Pd);

beta-thalassemia(Pd);

beta-thalassemia intermedia(Pd);

beta-thalassemia intermedia, dominant(Pd);

beta-thalassemia, Ashkenazi Jewish type(Pd);

Beta-thalassemia, dominant inclusion body type(Pd);

beta-thalassemia, dominant, Spanish type(Pd);

Beta-zero-thalassemia(Pd);

Hb Aubenas(Pd);

Hb Camperdown(Pd);

Hb Gambara(Pd);

Hb Niigata(Pd);

Hemoglobin 't Lange Land(Pd);

Hemoglobin Aalborg(Pd);

Hemoglobin Abruzzo(Pd);

Hemoglobin Agenogi(Pd);

Hemoglobin Alabama(Pd);

Hemoglobin Alamo(Pd);

Hemoglobin Alberta(Pd);

Hemoglobin Alesha(Pd);

Hemoglobin Altdorf(Pd);

Hemoglobin Andrew-Minneapolis(Pd);

Hemoglobin Ankara(Pd);

Hemoglobin Antalya(Pd);

Hemoglobin Arlington Park(Pd);

Hemoglobin Arta(Pd);

Hemoglobin Athens-Georgia(Pd);

Hemoglobin Atlanta(Pd);

Hemoglobin Atlanta-Coventry(Pd);

Hemoglobin Aubagne(Pd);

Hemoglobin Aurora(Pd);

Hemoglobin Austin(Pd);

Hemoglobin Avicenna(Pd);

Hemoglobin Bab-Saadoun(Pd);

Hemoglobin Baden(Pd);

Hemoglobin Barbizon(Pd);

Hemoglobin Barcelona(Pd);

Hemoglobin Beirut(Pd);

Hemoglobin Belfast(Pd);

Hemoglobin Beograd(Pd);

Hemoglobin beta variants, molecular defect unknown(Pd);

Hemoglobin Beth Israel(Pd);

Hemoglobin Bethesda(Pd);

Hemoglobin Bicetre(Pd);

Hemoglobin Birmingham(Pd);

Hemoglobin Bologna(Pd);

Hemoglobin Bologna-St. Orsola(Pd);

Hemoglobin Boras(Pd);

Hemoglobin Bougardirey-Mali(Pd);

Hemoglobin Brem-Sur-Mer(Pd);

Hemoglobin Brest(Pd);

Hemoglobin Brie Comte Robert(Pd);

Hemoglobin Brigham(Pd);

Hemoglobin Brisbane(Pd);

Hemoglobin Bristol(Pd);

Hemoglobin British Columbia(Pd);

Hemoglobin Brockton(Pd);

Hemoglobin Bruxelles(Pd);

Hemoglobin Bunbury(Pd);

Hemoglobin Burke(Pd);

Hemoglobin Burton-upon-Trent(Pd);

Hemoglobin Bushey(Pd);

Hemoglobin Bushwick(Pd);

Hemoglobin Buzen(Pd);

Hemoglobin C(Pd);

Hemoglobin C (Georgetown)(Pd);

Hemoglobin C (Ziguinchor)(Pd);

Hemoglobin Calais(Pd);

Hemoglobin Camden(Pd);

Hemoglobin Camperdown(Pd);

Hemoglobin Canterbury(Pd);

Hemoglobin Cardarelli(Pd);

Hemoglobin Caribbean(Pd);

Hemoglobin Casablanca(Pd);

Hemoglobin Castilla(Pd);

Hemoglobin Chandigarh(Pd);

Hemoglobin Chesterfield(Pd);

Hemoglobin Cheverly(Pd);

Hemoglobin Chico(Pd);

Hemoglobin Chile(Pd);

Hemoglobin Christchurch(Pd);

Hemoglobin City of Hope(Pd);

Hemoglobin Cleveland(Pd);

Hemoglobin Cochin-Port Royal(Pd);

Hemoglobin Cocody(Pd);

Hemoglobin Coimbra(Pd);

Hemoglobin Colima(Pd);

Hemoglobin Collingwood(Pd);

Hemoglobin Costa Rica(Pd);

Hemoglobin Coventry(Pd);

Hemoglobin Cowtown(Pd);

Hemoglobin Cranston(Pd);

Hemoglobin Crete(Pd);

Hemoglobin Creteil(Pd);

Hemoglobin D (Agri)(Pd);

Hemoglobin D (Bushman)(Pd);

Hemoglobin D (Granada)(Pd);

Hemoglobin D (Ibadan)(Pd);

Hemoglobin D (Iran)(Pd);

Hemoglobin D (Neath)(Pd);

Hemoglobin D (Ouled Rabah)(Pd);

Hemoglobin D (Punjab)(Pd);

Hemoglobin Debrousse(Pd);

Hemoglobin Deer Lodge(Pd);

Hemoglobin Denver(Pd);

Hemoglobin Detroit(Pd);

Hemoglobin Dhonburi(Pd);

Hemoglobin Dieppe(Pd);

Hemoglobin Djelfa(Pd);

Hemoglobin Doha(Pd);

Hemoglobin Duarte(Pd);

Hemoglobin Duino(Pd);

Hemoglobin E(Pd);

Hemoglobin E (Saskatoon)(Pd);

Hemoglobin Edmonton(Pd);

Hemoglobin Ernz(Pd);

Hemoglobin Extremadura(Pd);

Hemoglobin Fannin-Lubbock(Pd);

Hemoglobin Freiburg(Pd);

Hemoglobin Fukuoka(Pd);

Hemoglobin Fukuyama(Pd);

Hemoglobin G (Accra)(Pd);

Hemoglobin G (Copenhagen)(Pd);

Hemoglobin G (Coushatta)(Pd);

Hemoglobin G (Ferrara)(Pd);

Hemoglobin G (Galveston)(Pd);

Hemoglobin G (hsi-tsou)(Pd);

Hemoglobin G (Makassar)(Pd);

Hemoglobin G (San Jose)(Pd);

Hemoglobin G (Szuhu)(Pd);

Hemoglobin G (Taipei)(Pd);

Hemoglobin G (Taiwan-Ami)(Pd);

Hemoglobin Gainesville-GA(Pd);

Hemoglobin Galicia(Pd);

Hemoglobin Gavello(Pd);

Hemoglobin Geldrop St. Anna(Pd);

Hemoglobin Genova(Pd);

Hemoglobin Grange-Blanche(Pd);

Hemoglobin Graz(Pd);

Hemoglobin Grenoble(Pd);

Hemoglobin Gun Hill(Pd);

Hemoglobin Hacettepe(Pd);

Hemoglobin Hafnia(Pd);

Hemoglobin Hakkari(Pd);

Hemoglobin Hamadan(Pd);

Hemoglobin Hamilton(Pd);

Hemoglobin Hammersmith(Pd);

Hemoglobin Harrow(Pd);

Hemoglobin Heathrow(Pd);

Hemoglobin Helsinki(Pd);

Hemoglobin Henri Mondor(Pd);

Hemoglobin Higashitochigi(Pd);

Hemoglobin Hijiyama(Pd);

Hemoglobin Hikari(Pd);

Hemoglobin Himeji(Pd);

Hemoglobin Hinsdale(Pd);

Hemoglobin Hinwil(Pd);

Hemoglobin Hirose(Pd);

Hemoglobin Hiroshima(Pd);

Hemoglobin Hofu(Pd);

Hemoglobin Hokusetsu(Pd);

Hemoglobin Hope(Pd);

Hemoglobin Hoshida(Pd);

Hemoglobin Hotel-Dieu(Pd);

Hemoglobin Houston(Pd);

Hemoglobin Howick(Pd);

Hemoglobin Hradec Kralove(Pd);

Hemoglobin I (High Wycombe)(Pd);

Hemoglobin I (Toulouse)(Pd);

Hemoglobin Ilmenau(Pd);

Hemoglobin Indianapolis(Pd);

Hemoglobin Iowa(Pd);

Hemoglobin Iraq-Halabja(Pd);

Hemoglobin Istanbul(Pd);

Hemoglobin J (Altgeld Gardens)(Pd);

Hemoglobin J (Amiens)(Pd);

Hemoglobin J (Antakya)(Pd);

Hemoglobin J (Auckland)(Pd);

Hemoglobin J (Baltimore)(Pd);

Hemoglobin J (Bangkok)(Pd);

Hemoglobin J (Cairo)(Pd);

Hemoglobin J (Calabria)(Pd);

Hemoglobin J (Chicago)(Pd);

Hemoglobin J (Cordoba)(Pd);

Hemoglobin J (Daloa)(Pd);

Hemoglobin J (Europa)(Pd);

Hemoglobin J (Guantanamo)(Pd);

Hemoglobin J (Iran)(Pd);

Hemoglobin J (Kaohsiung)(Pd);

Hemoglobin J (Lens)(Pd);

Hemoglobin J (Lome)(Pd);

Hemoglobin J (Luhe)(Pd);

Hemoglobin J (Rambam)(Pd);

Hemoglobin J (Sicilia)(Pd);

Hemoglobin J (Taichung)(Pd);

Hemoglobin Jacksonville(Pd);

Hemoglobin Jamaica Plain(Pd);

Hemoglobin Jianghua(Pd);

Hemoglobin Johnstown(Pd);

Hemoglobin K (Ibadan)(Pd);

Hemoglobin K (Woolwich)(Pd);

Hemoglobin Kairouan(Pd);

Hemoglobin Kansas(Pd);

Hemoglobin Karlskoga(Pd);

Hemoglobin Kempsey(Pd);

Hemoglobin Kenitra(Pd);

Hemoglobin Khartoum(Pd);

Hemoglobin Knossos(Pd);

Hemoglobin Kochi(Pd);

Hemoglobin Kodaira II(Pd);

Hemoglobin Kofu(Pd);

Hemoglobin Koln(Pd);

Hemoglobin Korea(Pd);

Hemoglobin Koriyama(Pd);

Hemoglobin Korle-Bu(Pd);

Hemoglobin la Coruna(Pd);

Hemoglobin la Desirade(Pd);

Hemoglobin la Roche-Sur-Yon(Pd);

Hemoglobin las Palmas(Pd);

Hemoglobin Leiden(Pd);

Hemoglobin Limassol(Pd);

Hemoglobin Lincoln Park(Pd);

Hemoglobin Linkoping(Pd);

Hemoglobin Little Rock(Pd);

Hemoglobin Louisville(Pd);

Hemoglobin Lucknow(Pd);

Hemoglobin Lufkin(Pd);

Hemoglobin Lyon(Pd);

Hemoglobin M (Milwaukee 1)(Pd);

Hemoglobin M (Milwaukee 2)(Pd);

Hemoglobin M (Saskatoon)(Pd);

Hemoglobin Machida(Pd);

Hemoglobin Madrid(Pd);

Hemoglobin Malay(Pd);

Hemoglobin Malmo(Pd);

Hemoglobin Manhattan(Pd);

Hemoglobin Manukau(Pd);

Hemoglobin Maputo(Pd);

Hemoglobin Marineo(Pd);

Hemoglobin Marseille(Pd);

Hemoglobin Masuda(Pd);

Hemoglobin Matera(Pd);

Hemoglobin Mckees Rocks(Pd);

Hemoglobin Medicine Lake(Pd);

Hemoglobin Mequon(Pd);

Hemoglobin Minneapolis-Laos(Pd);

Hemoglobin Mississippi(Pd);

Hemoglobin Mito(Pd);

Hemoglobin Miyada(Pd);

Hemoglobin Miyashiro(Pd);

Hemoglobin Mizuho(Pd);

Hemoglobin Mizunami(Pd);

Hemoglobin Mobile(Pd);

Hemoglobin Molfetta(Pd);

Hemoglobin Mont Saint-Aignan(Pd);

Hemoglobin Montreal(Pd);

Hemoglobin Moriguchi(Pd);

Hemoglobin Moscva(Pd);

Hemoglobin Mozhaisk(Pd);

Hemoglobin Muscat(Pd);

Hemoglobin Muskegon(Pd);

Hemoglobin N (Baltimore)(Pd);

Hemoglobin N (Memphis)(Pd);

Hemoglobin N (Seattle)(Pd);

Hemoglobin N (Timone)(Pd);

Hemoglobin N, beta type(Pd);

Hemoglobin Nagasaki(Pd);

Hemoglobin Nagoya(Pd);

Hemoglobin Nakano(Pd);

Hemoglobin Nevers(Pd);

Hemoglobin New mexico(Pd);

Hemoglobin New York(Pd);

Hemoglobin Newcastle(Pd);

Hemoglobin Nijkerk(Pd);

Hemoglobin Nikosia(Pd);

Hemoglobin North Chicago(Pd);

Hemoglobin North Shore(Pd);

Hemoglobin Nottingham(Pd);

Hemoglobin O (Arab)(Pd);

Hemoglobin O (Tibesti)(Pd);

Hemoglobin Ocho Rios(Pd);

Hemoglobin Ohio(Pd);

Hemoglobin Okaloosa(Pd);

Hemoglobin Okayama(Pd);

Hemoglobin Okazaki(Pd);

Hemoglobin Olmsted(Pd);

Hemoglobin Olomouc(Pd);

Hemoglobin Olympia(Pd);

Hemoglobin Osler(Pd);

Hemoglobin Osu Christiansborg(Pd);

Hemoglobin P(Pd);

Hemoglobin P (Congo)(Pd);

Hemoglobin P (Nilotic)(Pd);

Hemoglobin Palmerston North(Pd);

Hemoglobin Pasadena(Pd);

Hemoglobin Perth(Pd);

Hemoglobin Peterborough(Pd);

Hemoglobin Philly(Pd);

Hemoglobin Pierre-Benite(Pd);

Hemoglobin Pitie-Salpetriere(Pd);

Hemoglobin Pocos de Caldas(Pd);

Hemoglobin Poissy(Pd);

Hemoglobin Porto Alegre(Pd);

Hemoglobin Potomac(Pd);

Hemoglobin Presbyterian(Pd);

Hemoglobin Providence(Pd);

Hemoglobin Puttelange(Pd);

Hemoglobin Pyrgos(Pd);

Hemoglobin Quebec-Chori(Pd);

Hemoglobin Quin-Hai(Pd);

Hemoglobin Radcliffe(Pd);

Hemoglobin Rahere(Pd);

Hemoglobin Rainier(Pd);

Hemoglobin Raleigh(Pd);

Hemoglobin Rancho Mirage(Pd);

Hemoglobin Randwick(Pd);

Hemoglobin Redondo(Pd);

Hemoglobin Regina(Pd);

Hemoglobin Renert(Pd);

Hemoglobin Richmond(Pd);

Hemoglobin Rio Claro(Pd);

Hemoglobin Rio Grande(Pd);

Hemoglobin Riverdale-Bronx(Pd);

Hemoglobin Riyadh(Pd);

Hemoglobin Rockford(Pd);

Hemoglobin Roseau-Pointe a Pitre(Pd);

Hemoglobin Rothschild(Pd);

Hemoglobin Rush(Pd);

Hemoglobin S(Pd);

Hemoglobin S (Antilles)(Pd);

Hemoglobin S (Oman)(Pd);

Hemoglobin S (Providence)(Pd);

Hemoglobin S (Travis)(Pd);

Hemoglobin Saale(Pd);

Hemoglobin Sabine(Pd);

Hemoglobin Sagami(Pd);

Hemoglobin Saint Nazaire(Pd);

Hemoglobin Saitama(Pd);

Hemoglobin Saki(Pd);

Hemoglobin San Diego(Pd);

Hemoglobin Santa ana(Pd);

Hemoglobin Santa Clara(Pd);

Hemoglobin Santander(Pd);

Hemoglobin Savannah(Pd);

Hemoglobin Saverne(None);

Hemoglobin Seattle(Pd);

Hemoglobin Sendagi(Pd);

Hemoglobin Shanghai(Pd);

Hemoglobin Shelby(Pd);

Hemoglobin Shepherds Bush(Pd);

Hemoglobin Sherwood Forest(Pd);

Hemoglobin Showa-Yakushiji(Pd);

Hemoglobin Silver Springs(Pd);

Hemoglobin Siriraj(Pd);

Hemoglobin Sitia(Pd);

Hemoglobin Sogn(Pd);

Hemoglobin South Florida(Pd);

Hemoglobin South Milwaukee(Pd);

Hemoglobin Southampton(Pd);

Hemoglobin Sparta(Pd);

Hemoglobin St. Antoine(Pd);

Hemoglobin St. Francis(Pd);

Hemoglobin St. Louis(Pd);

Hemoglobin St. Mande(Pd);

Hemoglobin Strasbourg(Pd);

Hemoglobin Summer Hill(Pd);

Hemoglobin Sunnybrook(Pd);

Hemoglobin Sydney(Pd);

Hemoglobin Syracuse(Pd);

Hemoglobin TA-lI(Pd);

Hemoglobin Tacoma(Pd);

Hemoglobin Tak(Pd);

Hemoglobin Takamatsu(Pd);

Hemoglobin Tampa(Pd);

Hemoglobin Tende(Pd);

Hemoglobin Terre Haute(Pd);

Hemoglobin Tianshui(Pd);

Hemoglobin Tigraye(Pd);

Hemoglobin Tilburg(Pd);

Hemoglobin Tizi-Puzou(Pd);

Hemoglobin Tours(Pd);

Hemoglobin Toyoake(Pd);

Hemoglobin Trento(Pd);

Hemoglobin Tripoli(Pd);

Hemoglobin Trollhaettan(Pd);

Hemoglobin Tsukumi(Pd);

Hemoglobin Tsurumai(Pd);

Hemoglobin Tubingen(Pd);

Hemoglobin Tunis(Pd);

Hemoglobin TY Gard(Pd);

Hemoglobin Tyne(Pd);

Hemoglobin Vaasa(Pd);

Hemoglobin Valletta(Pd);

Hemoglobin Vancouver(Pd);

Hemoglobin Vanderbilt(Pd);

Hemoglobin Vicksburg(Pd);

Hemoglobin Vila Real(Pd);

Hemoglobin Villaverde(Pd);

Hemoglobin Villejuif(Pd);

Hemoglobin Volga(Pd);

Hemoglobin Warwickshire(Pd);

Hemoglobin Washtenaw(Pd);

Hemoglobin Watford(Pd);

Hemoglobin Wien(Pd);

Hemoglobin Willamette(Pd);

Hemoglobin Windsor(Pd);

Hemoglobin Wood(Pd);

Hemoglobin Yahata(Pd);

Hemoglobin Yaizu(Pd);

Hemoglobin Yakima(Pd);

Hemoglobin Yamagata(Pd);

Hemoglobin Yaounde(Pd);

Hemoglobin Yatsushiro(Pd);

Hemoglobin Yokohama(Pd);

Hemoglobin York(Pd);

Hemoglobin Yoshizuka(Pd);

Hemoglobin Ypsilanti(Pd);

Hemoglobin Yukuhashi(Pd);

Hemoglobin Yusa(Pd);

Hemoglobin Zengcheng(Pd);

Hemoglobin Zoeterwoude(Pd);

Hemoglobin Zurich(Pd);

Thalassemia Intermedia(Pd)

Predicted Transmembrane Domains:

Isoform 1 : 0

Additional Identifiers:

HPRD:

00786

Entrez Gene ID:

3043

OMIM ID:

141900

Swissprot Accession:

P68871;

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Description for Protein HBB