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Description for Protein HBA2

hemoglobin, alpha 2
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 1)
Summary:
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K13822
KEGG - Pathway(s):
hsa05144
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
-
Approved Symbol:
HBA2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Alpha-plus-thalassemia(Pd);
  • Alpha-thalassemia(Pd);
  • Alpha-thalassemia trait(Pd);
  • Alpha-thalassemia, Dutch type(Pd);
  • Alpha-thalassemia, Hmong type(Pd);
  • Alpha-thalassemia, ZF type(Pd);
  • Alpha-thalassemia-2, nondeletional(Pd);
  • Hemoglobin Aakae(Pd);
  • Hemoglobin Agrinio(Pd);
  • Hemoglobin Al-Hammadi Riyadh(Pd);
  • Hemoglobin Anamosa(Pd);
  • Hemoglobin Antananarivo(Pd);
  • Hemoglobin Bibba(Pd);
  • Hemoglobin Boghe(Pd);
  • Hemoglobin Boyle Heights(Pd);
  • Hemoglobin Campinas(Pd);
  • Hemoglobin Chartres(Pd);
  • Hemoglobin Clinico-Madrid(Pd);
  • Hemoglobin Columbia Missouri(Pd);
  • Hemoglobin Conakry(Pd);
  • Hemoglobin Constant Spring(Pd);
  • Hemoglobin Dartmouth(Pd);
  • Hemoglobin Davenport(Pd);
  • Hemoglobin Decines-Charpieu(Pd);
  • Hemoglobin Evans(Pd);
  • Hemoglobin Fukui(Pd);
  • Hemoglobin G (Bristol)(Pd);
  • Hemoglobin G (Honolulu)(Pd);
  • Hemoglobin Gerland(Pd);
  • Hemoglobin H disease(Pd);
  • Hemoglobin Hanamaki(Pd);
  • Hemoglobin I(Pd);
  • Hemoglobin Icaria(Pd);
  • Hemoglobin Inkster(Pd);
  • Hemoglobin J (Buda)(Pd);
  • Hemoglobin J (Oxford)(Pd);
  • Hemoglobin J (Sardegna)(Pd);
  • Hemoglobin Koya Dora(Pd);
  • Hemoglobin Kurdistan(Pd);
  • Hemoglobin Kurosaki(Pd);
  • Hemoglobin l (Ferrara)(Pd);
  • Hemoglobin Lombard(Pd);
  • Hemoglobin Manawatu(Pd);
  • Hemoglobin Manitoba(Pd);
  • Hemoglobin Montgomery(Pd);
  • Hemoglobin Natal(Pd);
  • Hemoglobin Nikaia(Pd);
  • Hemoglobin Norton(Pd);
  • Hemoglobin Park Ridge(Pd);
  • Hemoglobin Part-Dieu(Pd);
  • Hemoglobin Passy(Pd);
  • Hemoglobin Plasencia(Pd);
  • Hemoglobin Prato(Pd);
  • Hemoglobin Quong Sze(Pd);
  • Hemoglobin Rampa(Pd);
  • Hemoglobin Sallanches(Pd);
  • Hemoglobin San Antonio(Pd);
  • Hemoglobin Seal Rock(None);
  • Hemoglobin Spanish Town(Pd);
  • Hemoglobin Suan-Dok(Pd);
  • Hemoglobin Sun Prairie(Pd);
  • Hemoglobin Tarrant(Pd);
  • Hemoglobin Toulon(Pd);
  • Hemoglobin val de Marne(Pd);
  • Hemoglobin Watts(Pd);
  • Hemoglobin Wayne(Pd);
  • Hemoglobin Zurich Albisrieden(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00785 Entrez Gene ID: 3040 OMIM ID: 141850 Swissprot Accession: P69905; D1MGQ2;