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Description for Protein HBA1

hemoglobin, alpha 1

5 total interacting proteins; 4 platelet interacting proteins

Platelet Evidence (proteome studies/others : 9/2)
(membrane: 2; microparticles: 1; platelet: 9; secretome: 2; undefined: 2)

Summary:

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq] (PubMed Links)

Domains and Motifs:

None Available

Gene Ontology:

Gene Ontology Annotations

KEGG - Enzyme ID(s):

None Available

KEGG - Orthology:

K13822

KEGG - Pathway(s):

hsa05144
(The yellow boxes represents platelet proteins)

Nomenclature / Alternative Names:

Approved Symbol:

HBA1

(De-) Phosphorylations:

Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5;	No platelet phosphorylation sites

Phosphorylation Targets:

Total phosphorylation targets: 0
Human phosphorylation targets: 0;	Predicted platelet targets: 0

Protein Characteristics:

Isoform-specific Information

Associated Drugs (DrugBank Accession):

1,3,5-BENZENETRICARBOXYLIC ACID(db);

2,6-DICARBOXYNAPHTHALENE(db);

2-[(2-methoxy-5-methylphenoxy)methyl]pyridine(db);

2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID(db);

2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID(db);

2-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID(db);

4-Carboxycinnamic Acid(db);

4-[(5-methoxy-2-methylphenoxy)methyl]pyridine(db);

Iron Dextran(db);

Mefloquine(db);

SEBACIC ACID(db)

Associated Genetic Diseases:

Alpha-thalassemia(Pd);

Hemoglobin Aghia Sophia(Pd);

Hemoglobin Aichi(Pd);

Hemoglobin Al-ain Abu Dhabi(Pd);

Hemoglobin Albany-Georgia(Pd);

Hemoglobin Alpha variants, molecular defect unknown(Pd);

Hemoglobin Anantharaj(Pd);

Hemoglobin Ann Arbor(Pd);

Hemoglobin Arya(Pd);

Hemoglobin Atago(Pd);

Hemoglobin Attleboro(Pd);

Hemoglobin Aztec(Pd);

Hemoglobin Bari(Pd);

Hemoglobin Beijing(Pd);

Hemoglobin Belliard(Pd);

Hemoglobin Beziers(Pd);

Hemoglobin Bibba(Pd);

Hemoglobin Bois Guillaume(Pd);

Hemoglobin Bourmedes(Pd);

Hemoglobin Broussais(Pd);

Hemoglobin Buffalo(Pd);

Hemoglobin Caen(Pd);

Hemoglobin Catonsville(Pd);

Hemoglobin Cemenelum(Pd);

Hemoglobin Chad(Pd);

Hemoglobin Chapel Hill(Pd);

Hemoglobin Charolles(Pd);

Hemoglobin Chesapeake(Pd);

Hemoglobin Chiapas(Pd);

Hemoglobin Chicago(Pd);

Hemoglobin Chongqing(Pd);

Hemoglobin Contaldo(Pd);

Hemoglobin Cordele(Pd);

Hemoglobin Dagestan(Pd);

Hemoglobin Daneshgah-Tehran(Pd);

Hemoglobin Delfzicht(Pd);

Hemoglobin Denmark Hill(Pd);

Hemoglobin Die(Pd);

Hemoglobin Douala(Pd);

Hemoglobin Duan(Pd);

Hemoglobin Dunn(Pd);

Hemoglobin Etobicoke(Pd);

Hemoglobin Evanston(Pd);

Hemoglobin Ferndown(Pd);

Hemoglobin Fontainebleau(Pd);

Hemoglobin Fort de France(Pd);

Hemoglobin Fuchu-I(Pd);

Hemoglobin Fukutomi(Pd);

Hemoglobin G (Audhali)(Pd);

Hemoglobin G (Fort Worth)(Pd);

Hemoglobin G (Georgia)(Pd);

Hemoglobin G (Norfolk)(Pd);

Hemoglobin G (Pest)(Pd);

Hemoglobin G (Taichung)(Pd);

Hemoglobin G (Waimanalo)(Pd);

Hemoglobin Godavari(Pd);

Hemoglobin Gouda(Pd);

Hemoglobin Grady(Pd);

Hemoglobin Guangzhou(Pd);

Hemoglobin Guizhou(Pd);

Hemoglobin Handa(Pd);

Hemoglobin Handsworth(Pd);

Hemoglobin Harbin(Pd);

Hemoglobin Hekinan(Pd);

Hemoglobin Hirosaki(Pd);

Hemoglobin Hobart(Pd);

Hemoglobin Hopkins 2(Pd);

Hemoglobin I(Pd);

Hemoglobin Iwata(Pd);

Hemoglobin J (Abidjan)(Pd);

Hemoglobin J (Anatolia)(Pd);

Hemoglobin J (Birmingham)(Pd);

Hemoglobin J (Biskra)(Pd);

Hemoglobin J (Camaguey)(Pd);

Hemoglobin J (Cape Town)(Pd);

Hemoglobin J (Cubujuqui)(Pd);

Hemoglobin J (Habana)(Pd);

Hemoglobin J (Kurosh)(Pd);

Hemoglobin J (Nyanza)(Pd);

Hemoglobin J (Paris 1)(Pd);

Hemoglobin J (Rajappen)(Pd);

Hemoglobin J (Rovigo)(Pd);

Hemoglobin J (Singa)(Pd);

Hemoglobin J (Singapore)(Pd);

Hemoglobin J (Tashikuergan)(Pd);

Hemoglobin J (Tongariki)(Pd);

Hemoglobin J (Toronto)(Pd);

Hemoglobin Jackson(Pd);

Hemoglobin Kanagawa(Pd);

Hemoglobin Karachi(Pd);

Hemoglobin Kariya(Pd);

Hemoglobin Kawachi(Pd);

Hemoglobin Koelliker(Pd);

Hemoglobin Kokura(Pd);

Hemoglobin l (Persian Gulf)(Pd);

Hemoglobin Lamen Island(Pd);

Hemoglobin le Lamentin(Pd);

Hemoglobin Legnano(Pd);

Hemoglobin Lille(Pd);

Hemoglobin Lisbon(Pd);

Hemoglobin Loire(Pd);

Hemoglobin Luton(Pd);

Hemoglobin Luxembourg(Pd);

Hemoglobin M (Boston)(Pd);

Hemoglobin M (Iwate)(Pd);

Hemoglobin Malhacen(Pd);

Hemoglobin Mantes-la-Jolie(Pd);

Hemoglobin Matsue-Oki(Pd);

Hemoglobin Melusine(Pd);

Hemoglobin Memphis(Pd);

Hemoglobin Mexico(Pd);

Hemoglobin Milledgeville(Pd);

Hemoglobin Miyano(Pd);

Hemoglobin Mizushi(Pd);

Hemoglobin Moabit(Pd);

Hemoglobin Montefiore(Pd);

Hemoglobin Mosella(Pd);

Hemoglobin Necker Enfants-Malades(Pd);

Hemoglobin Noko(Pd);

Hemoglobin Norfolk(Pd);

Hemoglobin Nouakchott(Pd);

Hemoglobin Nunobiki(Pd);

Hemoglobin O (Indonesia)(Pd);

Hemoglobin O (Padova)(Pd);

Hemoglobin Oegstgeest(Pd);

Hemoglobin Ogi(Pd);

Hemoglobin Oita(Pd);

Hemoglobin Oleander(Pd);

Hemoglobin Ottawa(Pd);

Hemoglobin Owari(Pd);

Hemoglobin Ozieri(Pd);

Hemoglobin Pavie(Pd);

Hemoglobin Perspolis(Pd);

Hemoglobin Petah Tikva(Pd);

Hemoglobin Poitiers(Pd);

Hemoglobin Pontoise(Pd);

Hemoglobin Port Huron(Pd);

Hemoglobin Port Phillip(Pd);

Hemoglobin Q (India)(Pd);

Hemoglobin Q (Iran)(Pd);

Hemoglobin Questembert(Pd);

Hemoglobin Reims(Pd);

Hemoglobin Riccarton(Pd);

Hemoglobin Roanne(Pd);

Hemoglobin Roubaix(Pd);

Hemoglobin Rouen(Pd);

Hemoglobin Russ(Pd);

Hemoglobin Saratoga Springs(Pd);

Hemoglobin Sassari(Pd);

Hemoglobin Savaria(Pd);

Hemoglobin Sawara(Pd);

Hemoglobin Setif(Pd);

Hemoglobin Shaare Zedek(Pd);

Hemoglobin Shenyang(Pd);

Hemoglobin Shimonoseki(Pd);

Hemoglobin Shuangfeng(Pd);

Hemoglobin Singapore(Pd);

Hemoglobin St. Luke's(Pd);

Hemoglobin Stanleyville-II(Pd);

Hemoglobin Strumica(Pd);

Hemoglobin Sunshine Seth(Pd);

Hemoglobin Suresnes(Pd);

Hemoglobin Swan River(Pd);

Hemoglobin Tamano(Pd);

Hemoglobin Tatras(Pd);

Hemoglobin Thailand(Pd);

Hemoglobin Thionville(Pd);

Hemoglobin Titusville(Pd);

Hemoglobin Tokoname(Pd);

Hemoglobin Tokyo(Pd);

Hemoglobin Tonosho(Pd);

Hemoglobin Torino(Pd);

Hemoglobin Tottori(Pd);

Hemoglobin Toyama(Pd);

Hemoglobin Tunis-Bizerte(Pd);

Hemoglobin Turriff(Pd);

Hemoglobin Twin Peaks(Pd);

Hemoglobin UBE-2(Pd);

Hemoglobin UBE-4(Pd);

Hemoglobin Villeurbanne(Pd);

Hemoglobin Westmead(Pd);

Hemoglobin Winnipeg(Pd);

Hemoglobin Woodville(Pd);

Hemoglobin Wuming(Pd);

Hemoglobin Yuda(Pd);

Hemoglobin Zaire(Pd);

Hemoglobin Zambia(Pd);

Thalassemia, alpha-plus(Pd)

Predicted Transmembrane Domains:

Isoform 1 : 0

Additional Identifiers:

HPRD:

00784

Entrez Gene ID:

3039

OMIM ID:

141800

Swissprot Accession:

P69905; D1MGQ2;

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Description for Protein HBA1