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Description for Protein HAS3

hyaluronan synthase 3
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.212
    KEGG - Orthology:
    K00752
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Hyaluronic acid synthase 3; Hyaluronan synthase 3 isoform b; EC 2.4.1.212; HA synthase 3; Hyaluronan synthase 3 isoform a
    Approved Symbol:
    HAS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 2
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 03889 Entrez Gene ID: 3038 OMIM ID: 602428 Swissprot Accession: O00219; Q8WTZ0; Q96RV2;