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Description for Protein HADH

hydroxyacyl-CoA dehydrogenase
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 7; secretome: 1)
Summary:
This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.35
    KEGG - Orthology:
    K00022
    KEGG - Pathway(s):
    hsa00062; hsa00071; hsa00280; hsa00310; hsa00380; hsa00650; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HADSC; EC 1.1.1.35; Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial; SCHAD; HCDH; Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; 3-@hydroxyacyl-CoA dehydrodenase
    Approved Symbol:
    HADH
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Hydroxybutyryl-Coenzyme A(db);
  • Acetoacetyl-Coenzyme A(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08372 Entrez Gene ID: 3033 OMIM ID: 601609 Swissprot Accession: Q16836;