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Description for Protein ANXA2

annexin A2
26 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 2; secretome: 3)
Summary:
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANX: Annexin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PAP-IV; LPC2D; CAL1H; Calpactin I heavy polypeptide; Chromobindin 8; Placental anticoagulant protein IV; Annexin A2 isoform 2; Annexin A2 isoform 1; ANX2; Annexin II, Heavy Chain; Lipocortin II; LPC2; LIP2; ANX2P1; ANX2P2; ANX2P3; p36; Annexin A2
    Approved Symbol:
    ANXA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 52
    Human (de-) phosphorylation sites: 52; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Tenecteplase(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01061 Entrez Gene ID: 302 OMIM ID: 151740 Swissprot Accession: P07355;