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Description for Protein GZMB

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
20 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.79
    KEGG - Orthology:
    K01353
    KEGG - Pathway(s):
    hsa04650; hsa04940; hsa05320; hsa05330; hsa05332
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytotoxic T lymphocyte ssociated serine esterase 1; CTLA1; Granzyme 2; Protease, serine B; CSPB; Cathepsin G like 1; CGL1; Fragmentin 2; T cell serine protease 1 3E; Cytotoxic T lymphocyte proteinase 2; Lymphocyte protease; SECT; CTSGL1; Human lymphocyte protein; HLP; C11; GRB
    Approved Symbol:
    GZMB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00476 Entrez Gene ID: 3002 OMIM ID: 123910 Swissprot Accession: Q67BC3; P10144;