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Description for Protein SH3KBP1

SH3-domain kinase binding protein 1
42 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12470
    KEGG - Pathway(s):
    hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SETA; HSB 1; CD2BP3; CD2 binding protein 3; Cbl interacting protein of 85 kDa; Human Src family kinase binding protein 1; Regulator of ubiquitous kinase (Ruk) protein,; MIG18; Migration-inducing gene 18 protein; c-Cbl-interacting protein; OTTHUMP00000061480; SH3-domain kinase binding protein 1 isoform b; SH3-domain kinase binding protein 1 isoform a
    Approved Symbol:
    SH3KBP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 40
    Human (de-) phosphorylation sites: 40; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02301 Entrez Gene ID: 30011 OMIM ID: 300374 Swissprot Accession: Q96B97; Q5JPT5; Q5JPT6;