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Description for Protein GYPC

glycophorin C (Gerbich blood group)
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06576
    KEGG - Pathway(s):
    hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GPC; Glycophorin D; GYPD; GPD; Sialoglycoprotein beta; Glycophorin C isoform 2; Glycophorin C isoform 1; GE; MGC126191; MGC126192; PAS-2; Glycoprotein beta; GLPC; Glycoconnectin; Sialoglycoprotein D
    Approved Symbol:
    GYPC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Glycophorin C, Gerbich variant(Pd);
  • Glycophorin C, Yus variant(Pd);
  • Glycophorin D, Duch variant(Pd);
  • Glycophorin D, Webb variant(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00193 Entrez Gene ID: 2995 OMIM ID: 110750 Swissprot Accession: P04921;