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Description for Protein ALG6

asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.-
    KEGG - Orthology:
    K03848
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Man(9)GlcNAc(2) PP Dol alpha 1,3 glucosyltransferase; My046 protein; Dolichyl pyrophosphate Man9GlcNAc2 alpha 1,3 glucosyltransferase
    Approved Symbol:
    ALG6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Congenital disorder of glycosylation, type Ic(Pd)
    		• Predicted Transmembrane Domains:
    05194_1(10)
    Additional Identifiers:

    HPRD: 05194 Entrez Gene ID: 29929 OMIM ID: 604566 Swissprot Accession: Q9Y672;