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Description for Protein EEF2K

eukaryotic elongation factor-2 kinase
19 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Alpha_kinase: Alpha-kinase family
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.20
    KEGG - Orthology:
    K08292
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    HSU93850; MGC45041; eEF 2 kinase; Calmodulin dependent protein kinase III; Calcium/calmodulin dependent eukaryotic elongation factor 2 kinase
    Approved Symbol:
    EEF2K
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 23
    Human (de-) phosphorylation sites: 23; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07369 Entrez Gene ID: 29904 OMIM ID: 606968 Swissprot Accession: O00418;