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Description for Protein ANAPC2

anaphase promoting complex subunit 2
14 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03349
KEGG - Pathway(s):
hsa04110; hsa04114; hsa04120; hsa04914
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
APC2; KIAA1406; Cyclosome subunit 2
Approved Symbol:
ANAPC2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 9
Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07367 Entrez Gene ID: 29882 OMIM ID: 606946 Swissprot Accession: Q9UJX6;