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Description for Protein GUCY2F

guanylate cyclase 2F, retinal
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • CC: Coiled Coil
  • GuCyclase: Adenylyl-/guanylyl cyclase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.6.1.2
    KEGG - Orthology:
    K12321
    KEGG - Pathway(s):
    hsa00230; hsa04744
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RETGC2; GC-F; Guanylate cyclase 2F; Guanylate cyclase 2F, retinal; Guanylate cyclase 2D-like, membrane (retina-specific); Rod outer segment membrane guanylate cyclase 2; Ros GC2; Guanylate cyclase F; GUC2F; GUC2DL
    Approved Symbol:
    GUCY2F
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 02078 Entrez Gene ID: 2986 OMIM ID: 300041 Swissprot Accession: P51841;