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Description for Protein GUCY1B3

guanylate cyclase 1, soluble, beta 3
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; microparticles: 1; platelet: 8)
Summary:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • GuCyclase: Adenylyl-/guanylyl cyclase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.6.1.2
    KEGG - Orthology:
    K12319
    KEGG - Pathway(s):
    hsa00230; hsa04270; hsa04540; hsa04730; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanylyl cyclase, soluble, beta-3; Guanylate cyclase soluble, beta-1 chain; GUCY1B1; GUC1B3; GUCSB3; GUCB3; GCS-beta-1; GCS-beta-3
    Approved Symbol:
    GUCY1B3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00769 Entrez Gene ID: 2983 OMIM ID: 139397 Swissprot Accession: Q02153;