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Description for Protein GUCY1A3

guanylate cyclase 1, soluble, alpha 3
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 11)
Summary:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit, such as alpha-1 (GUCY1A3), and a beta subunit, typically beta-1 (GUCY1B3; MIM 139397), catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • GuCyclase: Adenylyl-/guanylyl cyclase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.6.1.2
    KEGG - Orthology:
    K12318
    KEGG - Pathway(s):
    hsa00230; hsa04270; hsa04540; hsa04730; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanylyl cyclase soluble alpha-3; GUCA3; GCS-alpha-3; Soluble guanylate cyclase large subunit; GCS-alpha-1; GUCY1A1; GUC1A3; GUCSA3
    Approved Symbol:
    GUCY1A3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00768 Entrez Gene ID: 2982 OMIM ID: 139396 Swissprot Accession: Q02108; B3KU69;