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Description for Protein BRF1

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
12 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Two alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. Other transcript variants are possible, but their full-length natures have not been completely characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CYCLIN: domain present in cyclins, TFIIB and Retinoblastoma
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Transcription factor 3B 90kDa subunit; TATA box binding protein associated factor RNA polymerase 3 subunit 2; TBP associated factor RNA polymerase 3; General transcription factor 3B 90 kDa subunit; TATA box binding protein associated factor 3C; GTF3B, 90 kDa subunit; BRF; TAF3C; Transcription initiation factor IIIB isoform 3; Transcription initiation factor IIIB isoform 2; Transcription initiation factor IIIB isoform 1
    Approved Symbol:
    BRF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05361 Entrez Gene ID: 2972 OMIM ID: 604902 Swissprot Accession: Q92994;