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Description for Protein MSH6

mutS homolog 6 (E. coli)
25 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MUTSac: ATPase domain of DNA mismatch repair MUTS family
  • MUTSd: DNA-binding domain of DNA mismatch repair MUTS family
  • PWWP: domain with conserved PWWP motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08737
    KEGG - Pathway(s):
    hsa03430; hsa05200; hsa05210
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DNA mismatch repair protein MSH6; MutS alpha 160 kDa subunit; G/T mismatch binding protein; GTMBP; P160; GTBP
    Approved Symbol:
    MSH6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 36
    Human (de-) phosphorylation sites: 36; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Colon cancer, hereditary nonpolyposis, type 5(Pd);
  • Colorectal cancer, hereditary nonpolyposis, type 5(Pd);
  • Endometrial cancer, familial(Pd);
  • Ovarian cancer, endometrial type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07202 Entrez Gene ID: 2956 OMIM ID: 600678 Swissprot Accession: P52701; Q3SWU9;