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Description for Protein GSTP1

glutathione S-transferase pi 1
12 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.5.1.18
KEGG - Orthology:
K00799
KEGG - Pathway(s):
hsa00480; hsa00980; hsa00982; hsa05200; hsa05215
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glutathione S transferase, P1; GST3; GST, Class P1; Fatty acid ethyl ester synthase 3, myocardial; FAEES3; GSTPP; EC 2.5.1.18
Approved Symbol:
GSTP1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 7
Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene(db);
  • 1-(S-Glutathionyl)-2,4-Dinitrobenzene(db);
  • 2-(N-Morpholino)-Ethanesulfonic Acid(db);
  • 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID(db);
  • Carboxymethylenecysteine(db);
  • Cibacron Blue(db);
  • Clomipramine(db);
  • Glutathione(db);
  • Glutathione Sulfonic Acid(db);
  • Glycerol(db);
  • S-(4-BROMOBENZYL)CYSTEINE(db);
  • S-(P-Nitrobenzyl)Glutathione(db);
  • S-Hexylglutathione(db);
  • S-Hydroxycysteine(db);
  • S-NONYL-CYSTEINE(db)

    Associated Genetic Diseases:

  • Glutathione S-transferase pi polymorphism, type A(Pd);
  • Glutathione S-transferase pi polymorphism, type B(Pd);
  • Glutathione S-transferase pi polymorphism, type C(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00614 Entrez Gene ID: 2950 OMIM ID: 134660 Swissprot Accession: P09211;