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Description for Protein GSTM4

glutathione S-transferase mu 4
10 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.5.1.18
KEGG - Orthology:
K00799
KEGG - Pathway(s):
hsa00480; hsa00980; hsa00982
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GSTM4-4; GTS-Mu2; GST class-mu 4; Glutathione S-transferase, MU-4; Glutathione S-alkyltransferase M4; S-(hydroxyalkyl) glutathione lyase M4; Glutathione S-aryltransferase M4; Glutathione S-aralkyltransferase M4; EC 2.5.1.18; Glutathione S-transferase M4 isoform 2; Glutathione S-transferase M4 isoform 1
Approved Symbol:
GSTM4
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Hydroxy-2-S-Glutathionyl-3-Para-Nitrophenoxy-Propane(db);
  • Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine(db);
  • Glutathione(db);
  • Glutathione Sulfonic Acid(db);
  • S-Hexylglutathione(db);
  • S-Octylglutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00706 Entrez Gene ID: 2948 OMIM ID: 138333 Swissprot Accession: Q03013;