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Description for Protein GSTM1

glutathione S-transferase mu 1
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.5.1.18
KEGG - Orthology:
K00799
KEGG - Pathway(s):
hsa00480; hsa00980; hsa00982
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glutahione transferase class Mu, 1; Glutathione S-aralkyltransferase; Glutathione S-alkyltransferase; Glutathione S-transferase M1; Liver and fibroblast GST1; GST class-mu 1; HB subunit 4; GSTM1a-1a; GSTM1b-1b; GSTM1-1; GTH4; GST1; EC 2.5.1.18; Glutathione S-transferase M1 isoform 1; Glutathione S-transferase M1 isoform 2
Approved Symbol:
GSTM1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene(db);
  • (9s,10s)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene(db);
  • 1-(S-Glutathionyl)-2,4-Dinitrobenzene(db);
  • Fluorotryptophane(db);
  • Glutathione(db);
  • Glutathione S-(2,4 Dinitrobenzene)(db);
  • Zinc Trihydroxide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00707 Entrez Gene ID: 2944 OMIM ID: 138350 Swissprot Accession: P09488;