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Description for Protein GSS

glutathione synthetase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(microparticles: 1; platelet: 2; secretome: 1)
Summary:
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.2.3
KEGG - Orthology:
K01920
KEGG - Pathway(s):
hsa00480; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GSHS; EC 6.3.2.3; Glutathione synthase; GSH synthetase
Approved Symbol:
GSS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • Gamma-Glutamylcysteine(db);
  • Glutathione(db);
  • Glycine(db);
  • L-Cysteine(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Glutathione synthetase deficiency(Pd);
  • Glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03000 Entrez Gene ID: 2937 OMIM ID: 601002 Swissprot Accession: P48637;