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Description for Protein GSR

glutathione reductase
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 4; secretome: 2)
Summary:
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.8.1.7
    KEGG - Orthology:
    K00383
    KEGG - Pathway(s):
    hsa00480
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GR; GRase; Glutathione reductase, mitochondrial; EC 1.8.1.7
    Approved Symbol:
    GSR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE(db);
  • 3,6-Dihydroxy-Xanthene-9-Propionic Acid(db);
  • 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol(db);
  • 3-Sulfinoalanine(db);
  • 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID(db);
  • Carmustine(db);
  • Flavin-Adenine Dinucleotide(db);
  • Glutathione(db);
  • Glutathionylspermidine Disulfide(db);
  • Meta-Nitro-Tyrosine(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Oxidized Glutathione Disulfide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00704 Entrez Gene ID: 2936 OMIM ID: 138300 Swissprot Accession: P00390;