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Description for Protein GSN

gelsolin
29 total interacting proteins; 25 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 15/2)
(alpha granules: 2; membrane: 2; microparticles: 1; platelet: 10; secretome: 2; undefined: 2)
Summary:
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • GEL: Gelsolin homology domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05768
    KEGG - Pathway(s):
    hsa04666; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Actin depolymerizing factor; ADF; Brevin; AGEL; Gelsolin isoform b; Gelsolin isoform a
    Approved Symbol:
    GSN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-(17-Hydroxy-5,12-Dimethyl-3-Oxo-2,16-Dioxabicyclo[13.3.1]Nonadeca-4,8,10-Trien-17-Yl)-2-Thiazolidinone(db)

    Associated Genetic Diseases:

  • Amyloidosis, familial, Finnish type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00674 Entrez Gene ID: 2934 OMIM ID: 137350 Swissprot Accession: A2A418; Q5T0I2; P06396;