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Description for Protein GSK3A

glycogen synthase kinase 3 alpha
24 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 3; undefined: 1)
Summary:
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.26
    KEGG - Orthology:
    K08822
    KEGG - Pathway(s):
    hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GSK 3 alpha
    Approved Symbol:
    GSK3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 26
    Human (de-) phosphorylation sites: 26; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 41
    Human phosphorylation targets: 16; Predicted platelet targets: 25
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06002 Entrez Gene ID: 2931 OMIM ID: 606784 Swissprot Accession: P49840;