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Description for Protein PDIA3

protein disulfide isomerase family A, member 3
14 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/1)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 7; secretome: 1; undefined: 1)
Summary:
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.3.4.1
    KEGG - Orthology:
    K08056
    KEGG - Pathway(s):
    hsa04612
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glucose regulated protein 58KD; ERp60; ERp57; Disulfide isomerase ER60; 58 kDa microsomal protein; p58; ERp61; ER60; HIP70; Q2
    Approved Symbol:
    PDIA3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03625 Entrez Gene ID: 2923 OMIM ID: 602046 Swissprot Accession: P30101;