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Description for Protein SLC25A5

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; platelet: 4)
Summary:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05863
    KEGG - Pathway(s):
    hsa04020; hsa05012; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Adenine nucleotide translocator 2; ANT2; ADP/ATP translocator fibroblasts; ADP/ATP translocase 2; Adenine nucleotide translocator 2 (Fibroblast); ADP, ATP carrier protein, fibroblast isoform
    Approved Symbol:
    SLC25A5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Clodronate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 02147 Entrez Gene ID: 292 OMIM ID: 300150 Swissprot Accession: P05141; Q6NVC0;