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Description for Protein UHRF1

ubiquitin-like with PHD and ring finger domains 1
12 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBQ: Ubiquitin homologues
  • PHD: PHD zinc finger
  • NLS: Nuclear localization signal
  • RING: Ring finger
  • LZ: Leucine Zipper
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K10638
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ICBP90; Np95; RNF106; Inverted CCAAT box-binding protein, 90-KD; Nuclear phosphoprotein, 95-KD; Ubiquitin-like protein containing phd and ring finger domains 1; Ubiquitin-like, containing PHD and RING finger domains, 1 isoform 2; Ubiquitin-like, containing PHD and RING finger domains, 1 isoform 1
    Approved Symbol:
    UHRF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06992 Entrez Gene ID: 29128 OMIM ID: 607990 Swissprot Accession: Q2HIX7; A0JBR2; Q96T88;