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Description for Protein SLC25A4

solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
9 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 1)
Summary:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05863
    KEGG - Pathway(s):
    hsa04020; hsa05012; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ADP/ATP carrier protein heart/skeletal muscle isoform T1; ANT1; ADP/ATP translocator of skeletal muscle; ANT; ADP/ATP translocase 1; Adenine nucleotide translocator 1; PEO2; PEO3
    Approved Symbol:
    SLC25A4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db);
  • Carboxyatractyloside(db);
  • Cardiolipin(db);
  • Clodronate(db);
  • Di-Stearoyl-3-Sn-Phosphatidylcholine(db);
  • [3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium(db)

    Associated Genetic Diseases:

  • Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 00058 Entrez Gene ID: 291 OMIM ID: 103220 Swissprot Accession: P12235;