Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein GRLF1

glucocorticoid receptor DNA binding factor 1
7 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • Small_GTPase: Small GTPase of the Ras superfamily
  • ill-defined subfamily
  • FF: Contains two conserved F residues
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05732
    KEGG - Pathway(s):
    hsa04510; hsa04670; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p190A; GRF1; GREF1; Rho GAP p190A; Glucocorticoid receptor enhancing factor 1; KIAA1722; p190RhoGAP; Glucocorticoid receptor DNA binding factor 1 isoform b
    Approved Symbol:
    GRLF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 37
    Human (de-) phosphorylation sites: 37; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05592 Entrez Gene ID: 2909 OMIM ID: 605277 Swissprot Accession: Q9NRY4;