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Description for Protein NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
122 total interacting proteins; 55 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
  • HOLI: Ligand binding domain of hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05771
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GCR; GRL; GCCR; GR; Nuclear receptor subfamily 3, group C, member 1; Nuclear receptor subfamily 3, group C, member 1 isoform gamma; Nuclear receptor subfamily 3, group C, member 1 isoform alpha; Nuclear receptor subfamily 3, group C, member 1 isoform beta
    Approved Symbol:
    NR3C1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alclometasone(db);
  • Amcinonide(db);
  • B-Octylglucoside(db);
  • Beclomethasone(db);
  • Betamethasone(db);
  • Budesonide(db);
  • Ciclesonide(db);
  • Clobetasol(db);
  • Clocortolone(db);
  • Cortisone acetate(db);
  • Desonide(db);
  • Desoximetasone(db);
  • Dexamethasone(db);
  • Diflorasone(db);
  • Difluprednate(db);
  • Fludrocortisone(db);
  • Flumethasone Pivalate(db);
  • Flunisolide(db);
  • Fluocinolone Acetonide(db);
  • Fluocinonide(db);
  • Fluorometholone(db);
  • Fluoxymesterone(db);
  • Flurandrenolide(db);
  • Fluticasone Propionate(db);
  • Halobetasol Propionate(db);
  • Hexane-1,6-Diol(db);
  • Hydrocortamate(db);
  • Hydrocortisone(db);
  • Loteprednol(db);
  • Medrysone(db);
  • Megestrol(db);
  • Methylprednisolone(db);
  • Mifepristone(db);
  • Mometasone(db);
  • Paramethasone(db);
  • Prednicarbate(db);
  • Prednisolone(db);
  • Prednisone(db);
  • Rimexolone(db);
  • Triamcinolone(db)

    Associated Genetic Diseases:

  • Glucocorticoid receptor polymorphism(Pd);
  • Glucocorticoid resistance, cellular(Pd);
  • Glucocorticoid resistance, familial(Pd);
  • Glucocorticoid resistance, generalized(Pd);
  • Glucocorticoid resistance, relative(Pd);
  • Pseudohermaphroditism, female, with hypokalemia, due to glucocorticoid resistance(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00679 Entrez Gene ID: 2908 OMIM ID: 138040 Swissprot Accession: P04150;