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Description for Protein GRIN2D

glutamate receptor, ionotropic, N-methyl D-aspartate 2D
33 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PBPE: Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05212
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04720; hsa05010; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EB11; NR2D; Estrogen receptor binding CpG island; N-methyl D-aspartate receptor subtype 2D; Glutamate [NMDA] receptor subunit epsilon 4; N-methyl-D-aspartate receptor channel, subunit epsilon-4; Glutamate receptor, ionotropic, N-methyl D-aspartate subunit 2D
    Approved Symbol:
    GRIN2D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Glutamic Acid(db);
  • Meperidine(db);
  • Orphenadrine(db);
  • Tenocyclidine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 04095 Entrez Gene ID: 2906 OMIM ID: 602717 Swissprot Accession: O15399; Q59G17;