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Description for Protein GRIN2C

glutamate receptor, ionotropic, N-methyl D-aspartate 2C
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05211
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04720; hsa05010; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glutamate [NMDA] receptor subunit epsilon 3; NMDAR2C; Glutamate receptor ionotropic,; N-methyl D-aspartate receptor channel, subunit epsilon 3; N-methyl D-aspartate receptor subtype 2C; NR2C
    Approved Symbol:
    GRIN2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glycine(db);
  • L-Glutamic Acid(db);
  • Meperidine(db);
  • Tenocyclidine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00699 Entrez Gene ID: 2905 OMIM ID: 138254 Swissprot Accession: O15398; Q14957;