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Description for Protein GRIN2B

glutamate receptor, ionotropic, N-methyl D-aspartate 2B
43 total interacting proteins; 22 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PBPE: Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05210
    KEGG - Pathway(s):
    hsa04080; hsa04720; hsa05010; hsa05014; hsa05016; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glutamate [NMDA] receptor subunit epsilon 2; NMDAR2B; Glutamate receptor ionotropic, N-methyl D-aspartate subunit 2; N-methyl D-aspartate receptor channel, subunit epsilon 2; NR2B
    Approved Symbol:
    GRIN2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Felbamate(db);
  • Haloperidol(db);
  • L-Glutamic Acid(db);
  • Memantine(db);
  • Meperidine(db);
  • Tenocyclidine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00697 Entrez Gene ID: 2904 OMIM ID: 138252 Swissprot Accession: Q13224;