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Description for Protein GRIN2A

glutamate receptor, ionotropic, N-methyl D-aspartate 2A
26 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PBPE: Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05209
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04720; hsa05010; hsa05014; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glutamate receptor ionotropic, N-methyl D-aspartate subunit 2A; Glutamate [NMDA] receptor subunit epsilon 1; NMDAR2A; NR2A
    Approved Symbol:
    GRIN2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Felbamate(db);
  • Glycine(db);
  • Halothane(db);
  • L-Glutamic Acid(db);
  • Memantine(db);
  • Meperidine(db);
  • Tenocyclidine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 4
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00698 Entrez Gene ID: 2903 OMIM ID: 138253 Swissprot Accession: Q17RZ6; B4DII7; Q59EW6;