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Description for Protein GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1
55 total interacting proteins; 29 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05208
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04720; hsa05010; hsa05014; hsa05016
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NR1; NMDA1; NMDAR1; NMDA receptor 1; Glutamate [NMDA] receptor subunit zeta 1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMDA receptor 1 isoform NR1-3 precursor; NMDA receptor 1 isoform NR1-2 precursor; NMDA receptor 1 isoform NR1-1 precursor
    Approved Symbol:
    GRIN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (R)-4-Amino-Isoxazolidin-3-One(db);
  • Cycloleucine(db);
  • D-Serine(db);
  • Dcka, 5,7-Dichlorokynurenic Acid(db);
  • L-Glutamic Acid(db);
  • Meperidine(db);
  • Orphenadrine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 3
  • Isoform 2 : 3
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 15926 Entrez Gene ID: 2902 OMIM ID: 138249 Swissprot Accession: Q05586;