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Description for Protein GRIK2

glutamate receptor, ionotropic, kainate 2
18 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05202
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glutamate receptor 6; GluR6; Excitatory amino acid receptor 4; EAA4; MGC74427; Glutamate receptor 6 isoform 1 precursor; Glutamate receptor 6 isoform 2 precursor
    Approved Symbol:
    GRIK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2s,4r-4-Methylglutamate(db);
  • Amobarbital(db);
  • Aprobarbital(db);
  • Barbital(db);
  • Barbituric acid derivative(db);
  • Butabarbital(db);
  • Butalbital(db);
  • Butethal(db);
  • Domoic Acid(db);
  • Fucose(db);
  • Heptabarbital(db);
  • Hexobarbital(db);
  • L-Glutamic Acid(db);
  • Metharbital(db);
  • Methylphenobarbital(db);
  • Pentobarbital(db);
  • Phenobarbital(db);
  • Primidone(db);
  • Quisqualate(db);
  • Secobarbital(db);
  • Talbutal(db);
  • Thiopental(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 3
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 00692 Entrez Gene ID: 2898 OMIM ID: 138244 Swissprot Accession: A8K0H7; Q8IY40; Q13002;