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Description for Protein GRIA1

glutamate receptor, ionotropic, AMPA 1
24 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • PBPE: Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05197
    KEGG - Pathway(s):
    hsa04080; hsa04720; hsa04730; hsa05014
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glutamate receptor 1; GluR1; GluRA; GluR K1; GluHI; AMPA receptor 1
    Approved Symbol:
    GRIA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Desflurane(db);
  • Enflurane(db);
  • Isoflurane(db);
  • L-Glutamic Acid(db);
  • Methoxyflurane(db);
  • Phenobarbital(db);
  • Sevoflurane(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 3
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 00695 Entrez Gene ID: 2890 OMIM ID: 138248 Swissprot Accession: Q59GL5; P42261;