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Description for Protein RAPGEF1

Rap guanine nucleotide exchange factor (GEF) 1
14 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06277
    KEGG - Pathway(s):
    hsa04510; hsa04722; hsa04910; hsa05211
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanine nucleotide releasing protein C3G; GNRP; CRK SH3 binding GNRP; C3G; Rap guanine nucleotide exchange factor (GEF) 1; GRF2; DKFZp781P1719; Guanine nucleotide-releasing factor 2 isoform a; Guanine nucleotide-releasing factor 2 isoform b
    Approved Symbol:
    RAPGEF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 24
    Human (de-) phosphorylation sites: 24; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02627 Entrez Gene ID: 2889 OMIM ID: 600303 Swissprot Accession: Q13905; Q8IV73;