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Description for Protein GRB2

growth factor receptor-bound protein 2
271 total interacting proteins; 131 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/0)
(membrane: 1; microparticles: 1; platelet: 5; secretome: 1)
Summary:
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04364
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04320; hsa04510; hsa04540; hsa04630; hsa04650; hsa04660; hsa04662; hsa04664; hsa04722; hsa04910; hsa04912; hsa05200; hsa05211; hsa05213; hsa05214; hsa05215; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Growth factor receptor bound protein 2; ASH; Abundant Src homology protein; Growth factor receptor-bound protein 2 isoform 1; Growth factor receptor-bound protein 2 isoform 2
    Approved Symbol:
    GRB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid(db);
  • Pegademase bovine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00150 Entrez Gene ID: 2885 OMIM ID: 108355 Swissprot Accession: P62993; B0LPF3;