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Description for Protein GPX4

glutathione peroxidase 4 (phospholipid hydroperoxidase)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 3)
Summary:
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.11.1.9
    KEGG - Orthology:
    K00432
    KEGG - Pathway(s):
    hsa00480; hsa00590
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phospholipid hydroperoxidase; Sperm nucleus glutathione peroxidase; Glutathione peroxidase 4 (phospholipid hydroperoxidase); Phospholipid hydroperoxide glutathione peroxidase mitochondrial; snGPx; PHGPx; EC 1.11.1.12; Glutathione peroxidase 4 isoform A precursor; Glutathione peroxidase 4 isoform B precursor; Glutathione peroxidase 4 isoform C precursor
    Approved Symbol:
    GPX4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11819 Entrez Gene ID: 2879 OMIM ID: 138322 Swissprot Accession: P36969;