Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein GPX1

glutathione peroxidase 1
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(membrane: 1; microparticles: 1; platelet: 8; secretome: 1)
Summary:
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.11.1.9
KEGG - Orthology:
K00432
KEGG - Pathway(s):
hsa00480; hsa00590; hsa05014; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GSHPX1; MGC14399; EC 1.11.1.9; MGC88245; Glutathione peroxidase 1 isoform 1; glutathione peroxidase 1 isoform 2
Approved Symbol:
GPX1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glutathione(db)

    Associated Genetic Diseases:

  • Glutathione peroxidase polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11749 Entrez Gene ID: 2876 OMIM ID: 138320 Swissprot Accession: P07203;